The safest place to be during a tornado is in an underground shelter, including a basement. If such a shelter is not available, seek out an interior room on the lowest level of a well-constructed home or office building away from windows and doors. This may be an interior bathroom or a closet. Your goal should be to place as many walls and floors between you and the outside as
| County(s) Affected | Rating | Date | Time (LST) |
| Greenville-SC, Spartanburg-SC | F3 | May 10, 1952 | 1400 |
| Abbeville-SC, Greenwood-SC | F4 | March 31, 1973 | 1820 |
| Greenville-SC, Spartanburg-SC, Cherokee-SC, Cleveland-NC | F3 | May 27, 1973 | 1720 |
| Laurens-SC | F3 | December 13, 1973 | 1353 |
| Greenwood-SC | F4 | December 13, 1973 | 1430 |
| Anderson-SC | F3 | April 8, 1974 | 1533 |
| Spartanburg-SC, Cherokee-SC, Rutherford-NC | F4 | May 5, 1989 | 1620 |
| Cleveland-NC, Lincoln-NC, Catawba-NC | F4 | May 5, 1989 | 1654 |
| Union-NC | F4 | May 5, 1989 | 1801 |
| Habersham-GA | F3 | November 15, 1989 | 1801 |
| Union-NC | F3 | October 18, 1990 | 1500 |
| Habersham-GA, Rabun-GA, Oconee-SC | F3 | March 27, 1994 | 1504 |
| York-SC, Mecklenburg-NC | F3 | March 27, 1994 | |
| Caldwell-NC | F4 | May 7, 1998 | 1649 |
| Habersham-GA, Rabun-GA | EF3 | April 27, 2011 | 2300 |
| Oconee-SC | EF3 | April 13, 2020 | 0341 |